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Microbleeds in ischemic stroke are associated with lower serum adiponectin and higher soluble E-selectin levels

Zhixin Huang1, Qin Yin, Wen Sun

  • 1Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 21002, China; Department of Neurology, First Teaching Hospital of Fujian Medical University, Putian 351100, China.

Journal of the Neurological Sciences
|August 31, 2013
PubMed
Abstract

Insights

High adiponectin levels may protect against cerebral microbleeds (CMBs), while soluble E-selectin is linked to their increased prevalence. This suggests endothelial dysfunction plays a role in CMBs.

Area of Science:

  • Neurology
  • Vascular Biology
  • Biomarkers

Background:

  • Cerebral microbleeds (CMBs) are key indicators of cerebral small vessel disease.
  • The role of endothelial dysfunction in CMB development remains unclear.
  • This study investigates the relationship between specific biomarkers and CMB prevalence.

Purpose of the Study:

  • To explore the correlation between serum levels of adiponectin and soluble E-selectin (sE-selectin) and the presence of CMBs.
  • To assess the potential role of endothelial dysfunction in the pathogenesis of CMBs.

Main Methods:

  • Prospective study of 126 patients with first-ever ischemic stroke.
  • Detection and evaluation of CMBs using susceptibility-weighted magnetic resonance imaging.
  • Measurement of serum adiponectin and sE-selectin levels.

Main Results:

  • CMBs were detected in 50% of patients, more common in mixed brain regions.
  • Increased adiponectin levels showed a significant inverse association with CMB prevalence (OR = 0.55).
  • Elevated sE-selectin levels demonstrated a significant positive association with CMB prevalence (OR = 1.09).
  • sE-selectin and adiponectin levels were inversely correlated (r = -0.452, p = 0.001).

Conclusions:

  • Endothelial injury is implicated in the pathogenesis of CMBs.
  • Serum adiponectin and sE-selectin levels are closely associated with CMBs.
  • Adiponectin may exert a protective effect against the prevalence of CMBs.
Keywords:
AdiponectinCerebral microbleedsEndothelial dysfunctionIschemic strokeMarkersE-selectin

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