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Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes

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Published on: December 13, 2016

Mathematical modeling of the coating process.

Gregor Toschkoff¹, Johannes G Khinast

¹Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, Graz, Austria.

International Journal of Pharmaceutics

|August 31, 2013

Summary

This study reviews mathematical modeling and computational simulations for tablet coating. These approaches offer deeper insights into the coating process, aiding pharmaceutical quality control.

Keywords:

Computational Fluid Dynamics (CFD)Discrete Element Method (DEM)Film coating Modeling Pharmaceutical Engineering Tablet coating

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Area of Science:

Pharmaceutical Engineering
Chemical Process Modeling
Materials Science

Background:

Tablet coating is a critical pharmaceutical manufacturing step requiring strict quality control.
Experimental studies alone provide limited mechanistic understanding of the coating process.
Mathematical models are essential for interpreting experimental data and achieving process comprehension.

Purpose of the Study:

To provide a comprehensive overview of modeling and simulation techniques applied to tablet coating.
To explore various aspects of coating processes, including scale-up and mass uniformity.
To present and compare analytical and computational modeling concepts for tablet coating.

Main Methods:

Review of analytical modeling approaches for tablet coating.
Analysis of computational simulation techniques for pharmaceutical coating processes.
Investigation of models for critical parameters like drop atomization and coating uniformity.

Main Results:

Combined analytical and computational modeling offers enhanced insights into tablet coating mechanisms.
Modeling aids in addressing challenges such as scale-up and achieving uniform coating mass.
Comparison of different modeling concepts highlights their respective strengths and applications.

Conclusions:

Modeling and simulation are indispensable tools for mechanistic understanding and optimization of tablet coating.
These approaches facilitate the development of robust processes that meet stringent pharmaceutical quality standards.
The integration of diverse modeling strategies enables comprehensive analysis from fundamental principles to practical applications.