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Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

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Incus necrosis after irradiation.

Liselotte J C Rotteveel¹, Ulrich Siekman, Thomas E Linder

¹*Department of Otolaryngology, Head and Neck Surgery, LUMC, Leiden, The Netherlands; †HNO-Praxis, Glarus; and ‡Department of Otolaryngology, Head and Neck Surgery, Luzerner Kantonsspital, Luzern, Switzerland.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology

|August 31, 2013

Summary

This summary is machine-generated.

Osteoradionecrosis (ORN) of the ossicular chain can be an isolated complication after radiotherapy, causing conductive hearing loss. This case confirms ORN of the incus as a sole entity, presenting with low-frequency hearing loss.

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Area of Science:

Otolaryngology
Radiation Oncology
Pathology

Background:

Osteoradionecrosis (ORN) of the temporal bone is a rare, late complication following radiotherapy for head and neck or skull base tumors.
ORN can manifest in localized or diffuse forms, potentially leading to various otological and intracranial complications.
Previous reports suggest ossicular chain involvement in ORN is unlikely as an isolated finding.

Observation:

A 13-year-old boy presented with unilateral mixed hearing loss as his only otological symptom.
The patient had a history of radiotherapy for an anaplastic ependymoma 10 years prior.
Middle ear inspection revealed osteoradionecrosis of the incus.

Findings:

Histological investigation confirmed osteoradionecrosis of the incus.
This finding supports the possibility of isolated ORN of the ossicular chain.
The patient's hearing loss was predominantly conductive and affected low frequencies.

Implications:

Osteoradionecrosis of the ossicular chain can occur as an isolated complication.
Conductive hearing loss, particularly in low frequencies, may indicate isolated ORN of the ossicular chain.
Middle ear inspection and potential ossicular chain reconstruction are recommended, with awareness of risks like tympanic membrane injury and delayed healing.