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Updated: May 8, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Towards design principles for determining the mechanical stability of proteins
Toni Hoffmann1, Katarzyna M Tych, Megan L Hughes
1School of Physics and Astronomy, University of Leeds, Leeds, UKLS2 9JT. L.Dougan@leeds.ac.uk.
Abstract:
The successful integration of proteins into bionanomaterials with specific and desired functions requires an accurate understanding of their material properties. Two such important properties are their mechanical stability and malleability. While single molecule manipulation techniques now routinely provide access to these, there is a need to move towards predictive tools that can rationally identify proteins with desired material properties. We provide a comprehensive review of the available experimental data on the single molecule characterisation of proteins using the atomic force microscope. We uncover a number of empirical relationships between the measured mechanical stability of a protein and its malleability, which provide a set of simple tools that might be employed to estimate properties of previously uncharacterised proteins.
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