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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Related Experiment Video

Updated: May 8, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation therapy: retinal tumors.

Roshan V Sethi¹, Shannon M MacDonald, David Y Kim

¹Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Developments in Ophthalmology

|August 31, 2013

Summary

Radiotherapy (RT) is crucial for treating retinoblastoma (RB) and other retinal tumors. Despite concerns about secondary cancers in RB1 gene mutation carriers, RT advancements improve precision and safety for hereditary retinoblastoma patients.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

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Published on: December 28, 2017

Area of Science:

Ophthalmology
Radiation Oncology
Oncology

Background:

Retinoblastoma (RB) is the primary retinal tumor necessitating radiotherapy (RT).
RT is also employed for select cases of retinal capillary hemangioma and lymphoma.
Concerns exist regarding RT-induced second malignancies in patients with germline RB1 gene mutations.

Purpose of the Study:

To highlight the importance of radiotherapy in managing retinoblastoma.
To discuss the role of RT in other retinal tumors.
To address the risks and advancements in RT for hereditary retinoblastoma.

Main Methods:

Review of current radiotherapy applications in retinal tumors.
Discussion of technical innovations enhancing RT precision.
Analysis of risks associated with RT in hereditary retinoblastoma.

Main Results:

Radiotherapy remains a vital treatment modality for intraocular and extraocular retinoblastoma.
Technical advancements in RT enable precise tumor targeting and reduced exposure to healthy tissues.
These innovations are particularly beneficial for hereditary retinoblastoma patients at risk for additional malignancies.

Conclusions:

Radiotherapy is indispensable for retinoblastoma management.
Modern RT techniques mitigate risks, especially for hereditary cases.
Continued innovation in RT is essential for optimizing outcomes in retinal tumor treatment.