Related Experiment Video
Updated: May 8, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
The formulation development and stability of metronidazole suspension
K S Alexander1, S S K S Vangala, D Dollimore
1Industrial Pharamacy Division, Department of Pharmacy Practice, College of Pharmacy, The University of Toledo, Toledo, OH.
Abstract:
The purpose of this study was to extemporaneously formulate a liquid dosage form from commercially available tablets and establish the chemical stability of the drug. A suspension of metronidazole (15 mg/mL) was formulated from 500-mg metronidazole tablets. Stability-indicating, high-performance liquid chromatography assay procedures were utilized to analyze the concentration of the drug. Chemical stability was predicted using accelerated stability studies conducted at four temperatures, namely, 40 deg, 50 deg, 60 deg, and 70 deg C for metronidazole. The Arrhenius plot was used to predict the shelf-life of the metronidazole suspension at room temperature. The shelf-life was calculated from the initial concentration and k0 was found to be 73 years. Howwever, it would be more reasonable to expect that a quantity lasting no more than 90 days should be prepared and dispensed.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Drug Product Stability
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Clinically Relevant Drug Product Specifications: Methods of Establishment
