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Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

Published on: September 17, 2014

[Refractive changes after Descemet membrane endothelial keratoplasty].

T Röck¹, K U Bartz-Schmidt, D Röck

¹Department für Augenheilkunde, Eberhard-Karls-Universität Tübingen, Schleichstr. 12, 72076, Tübingen, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

|August 31, 2013

Summary

Descemet membrane endothelial keratoplasty (DMEK) shows minimal refractive changes. This study found a slight hyperopic shift after DMEK, unlike traditional penetrating keratoplasty, due to reduced corneal swelling.

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Area of Science:

Ophthalmology
Corneal Surgery
Refractive Error

Context:

Penetrating keratoplasty (PK) can lead to significant refractive disadvantages, including induced astigmatism and unpredictable refractive outcomes.
Posterior lamellar keratoplasty techniques aim to minimize these refractive complications.
Endothelial decompensation necessitates corneal transplantation for visual restoration.

Purpose:

To evaluate refractive changes following Descemet membrane endothelial keratoplasty (DMEK).
To compare refractive outcomes of DMEK with known outcomes of penetrating keratoplasty.
To assess the impact of DMEK on corneal thickness and refractive error.

Summary:

A retrospective study analyzed 139 eyes undergoing DMEK for endothelial decompensation.

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Last Updated: May 8, 2026

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

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Mean spherical equivalent showed a slight hyperopic shift (+0.37 D), and cylinder changed by -0.45 D post-DMEK.

Mean central corneal thickness decreased significantly from 670 µm to 544 µm, indicating reversal of stromal swelling.

Impact:

DMEK offers a favorable refractive outcome compared to PK, with minimal induced hyperopic shift.
The reduction in corneal thickness post-DMEK contributes to refractive stability.
These findings support DMEK as a refractive-sparing alternative for endothelial dysfunction.