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Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...

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Related Experiment Video

Updated: May 8, 2026

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
10:51

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A High-Voltage Integrated Circuit Engine for a Dielectrophoresis-based Programmable Micro-Fluidic Processor.

K Wayne Current1, Kelvin Yuk, Charles McConaghy

  • 1University of California, Davis, CA 95616.

Proceedings ... International Conference on MEMS, NANO, and Smart Systems. International Conference on MEMS, NANO, and Smart Systems
|August 31, 2013
PubMed
Summary
This summary is machine-generated.

A novel high-voltage integrated circuit enables programmable droplet transport using dielectrophoresis (DEP) forces. This micro-fluidic lab-on-a-chip system offers precise control for lab automation and diagnostics.

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Area of Science:

  • Microfluidics
  • Integrated Circuits
  • Biotechnology

Background:

  • Microfluidic systems require precise fluid manipulation for applications like lab-on-a-chip devices.
  • Dielectrophoresis (DEP) is a technique used to move microparticles and droplets using non-uniform electric fields.
  • Existing DEP systems often face limitations in programmability and integration.

Purpose of the Study:

  • To demonstrate a high-voltage integrated circuit for programmable droplet transport.
  • To develop the core engine for a DEP-based micro-fluidic lab-on-a-chip system.
  • To enable precise movement and injection of droplets using DEP forces.

Main Methods:

  • Fabrication of a 32x32 electrode driver array using 130V SOI CMOS technology.
  • Implementation of a high-voltage integrated circuit capable of generating DEP forces.
  • Utilizing variable electrode excitation voltage and frequency (up to 200Hz) with a 100V peak-to-peak waveform.
  • Achieving data communication rates up to 250kHz.

Main Results:

  • Successful demonstration of droplet transport along programmable paths on the circuit's coated surface.
  • The integrated circuit effectively creates DEP forces for droplet manipulation and injection.
  • The chip operates with a maximum power dissipation of 1.87W and measures 10.4 mm × 8.2 mm.

Conclusions:

  • The developed high-voltage integrated circuit serves as a robust engine for DEP-based micro-fluidic systems.
  • This technology facilitates precise, programmable droplet control, advancing lab-on-a-chip capabilities.
  • The system holds potential for enhanced automation in various scientific and diagnostic applications.