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Ondansetron Suppositories: Extemporaneous Preparation, Drug Release, Stability and Flux through Rabbit Rectal
S N Tenjarla1, E S Ward, J L Fox
1Southern School of Pharmacy, Mercer University, Atlanta, GA.
International Journal of Pharmaceutical Compounding
|August 31, 2013
Summary
Extemporaneously prepared ondansetron suppositories demonstrated good stability and drug release over 28 days. This formulation is feasible for clinical use, offering a viable alternative for ondansetron delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Formulation Development
Background:
- Ondansetron is commonly administered orally for nausea and vomiting.
- Alternative delivery routes may be necessary for patients unable to take oral medication.
- Suppository formulations offer a potential rectal route for ondansetron administration.
Purpose of the Study:
- To assess the feasibility of extemporaneously preparing ondansetron suppositories.
- To develop and characterize ondansetron suppositories using commercial bases.
- To evaluate the stability and drug release profiles of these suppositories.
Main Methods:
- Ondansetron suppositories (8 and 16 mg) were formulated using hydrophobic and hydrophilic bases.
- Stability was assessed over 28 days at 5°C.
- Drug release and in vitro ondansetron flux across rabbit rectal membrane were determined.
Main Results:
- Over 90% of ondansetron remained stable in both formulations after 28 days of refrigerated storage.
- No significant differences in drug release profiles were observed during the storage period.
- In vitro flux values indicated potential for rectal absorption, though variability requires further investigation.
Conclusions:
- Extemporaneous preparation of ondansetron suppositories is feasible using available components.
- The developed suppository formulations exhibit adequate stability and drug release characteristics.
- Rectal administration of ondansetron via these suppositories is a reasonable consideration for clinical practice.
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