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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: May 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial.

Karin Oechsle1, Zeynep Aslan, Yvonne Suesse

  • 1Pneumology Section, Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Eppendorf, Hamburg, Germany.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|August 31, 2013
PubMed
Summary

Multimodal exercise, including aerobic and strength training, improved physical performance and reduced side effects in hospitalized cancer patients undergoing chemotherapy. This intervention enhanced physical functioning and decreased fatigue and nausea.

Related Experiment Videos

Last Updated: May 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

  • Oncology
  • Exercise Physiology
  • Rehabilitation Medicine

Background:

  • Cancer and its treatments significantly impair physical performance.
  • Hospitalized cancer patients undergoing myeloablative chemotherapy experience substantial side effects.
  • Maintaining physical function is crucial for cancer patient recovery and quality of life.

Purpose of the Study:

  • To evaluate the impact of multimodal aerobic and strength exercises on physical performance in hospitalized cancer patients receiving myeloablative chemotherapy.
  • To assess the effects of a supervised exercise program on treatment-related side effects and quality of life.

Main Methods:

  • A prospective pilot study involving 48 cancer patients randomly assigned to a training group (TG) or control group (CG).
  • The TG engaged in 20-minute supervised ergometer and strength exercises five times weekly during chemotherapy.
  • Physical performance, lung function, muscle strength, quality of life, and fatigue were assessed.

Main Results:

  • The TG showed significant improvements in physical performance (8.96 ± 24 W) compared to the CG (-7.24 ± 20 W, p=0.02).
  • Increased oxygen consumption and expiratory minute ventilation were observed in the TG.
  • The TG reported less need for antiemetics and experienced reduced fatigue, with improved cognitive and psychosocial function post-chemotherapy.

Conclusions:

  • Multimodal exercise interventions demonstrate significant benefits for physical performance and functioning in cancer patients during chemotherapy.
  • Exercise positively impacts treatment-related symptoms, including fatigue and nausea.
  • Enhanced physical activity programs should be considered for hospitalized cancer patients during treatment.