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Accuracy in prescriptions compounded by pharmacy students
1Pharmaceutical Care Laboratories, Division of Pharmaceutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC.
International Journal of Pharmaceutical Compounding
|August 31, 2013
Summary
Most compounded prescriptions lack accuracy analysis. Student compounding accuracy for diphenhydramine hydrochloride was assessed, with most achieving +/- 10% accuracy, suggesting this as a practical standard for pharmacists.
Area of Science:
- Pharmaceutical Sciences
- Compounding Accuracy
- Quality Control in Pharmacy
Background:
- Compounded prescriptions often lack rigorous accuracy verification.
- Current standards assume a +/- 5% accuracy for compounded medications.
- Ensuring accuracy in extemporaneous compounding is critical for patient safety.
Purpose of the Study:
- To assess the compounding accuracy of pharmacy students for diphenhydramine hydrochloride.
- To determine a realistic accuracy benchmark for extemporaneous prescription compounding.
Main Methods:
- Two classes of pharmacy students received training on compounding techniques.
- Students compounded a diphenhydramine hydrochloride prescription over two attempts.
- Accuracy was measured against the labeled claim using a +/- 5% and +/- 10% margin.
Main Results:
- After two attempts, 62%-68% of students achieved +/- 5% accuracy.
- A higher percentage, 84%-96%, achieved +/- 10% accuracy.
- This indicates variability in achieving the strictest accuracy standards.
Conclusions:
- Extemporaneous compounding accuracy can vary significantly.
- An accuracy of +/- 10% of the labeled claim is a more achievable expectation for pharmacists.
- Further research may be needed to optimize compounding procedures for greater precision.
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