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Stability of albuterol in continuous nebulization
1College of Pharmacy, University of South Carolina, Columbia, SC.
Abstract:
Due to the emergent nature of situations requiring continuous nebulization of albuterol a premixed albuterol solution would provide faster access to the therapy when required. The purpose of this study was to evaluate the stability of albuterol solutions at a concentration (200 micrograms/mL) used in continuous nebulization when stored in various containers of polyvinyl chloride bags, polyolefin bags, polypropylene syringes and tubes and borosilicate glass tubes. Solutions were prepared in triplicate in 0.9% sodium chloride stored under refrigerated and room temperatures for seven days. Samples were removed and analyzed using a stability-indicating high-performance liquid chromatrography assay method. Albuterol was found to be stable (greater than 90% of the initial concentration remaining) for at least seven days in all five types of containers under the conditions tested.
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