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Stability of albuterol in continuous nebulization
1College of Pharmacy, University of South Carolina, Columbia, SC.
International Journal of Pharmaceutical Compounding
|August 31, 2013
Summary
Premixed albuterol solutions are stable for continuous nebulization therapy. Albuterol remained stable for seven days in various containers, ensuring faster access to this critical asthma treatment.
Area of Science:
- Pharmacology
- Pharmaceutical Sciences
- Clinical Pharmacy
Background:
- Continuous nebulization of albuterol is crucial for emergent respiratory conditions.
- A premixed albuterol solution offers potential for faster administration during critical events.
Purpose of the Study:
- To assess the stability of albuterol solutions at a concentration of 200 micrograms/mL.
- To evaluate albuterol stability in various storage containers and conditions relevant to clinical use.
Main Methods:
- Albuterol solutions (200 µg/mL) were prepared in triplicate using 0.9% sodium chloride.
- Solutions were stored in polyvinyl chloride bags, polyolefin bags, polypropylene syringes/tubes, and borosilicate glass tubes.
- Stability was assessed over seven days at refrigerated and room temperatures using a stability-indicating HPLC assay.
Main Results:
- Albuterol demonstrated stability in all tested containers over a seven-day period.
- More than 90% of the initial albuterol concentration remained in all samples.
- No significant degradation was observed under the tested storage conditions.
Conclusions:
- Premixed albuterol solutions are stable for at least seven days in common pharmaceutical containers.
- This stability supports the feasibility of using premixed solutions for continuous nebulization therapy.
- Faster access to albuterol via premixed solutions can be achieved without compromising drug integrity.
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