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Updated: May 8, 2026
Glucose-Stimulated Insulin Secretion via Perfusion through the Mice Vasculature with an Intact Pancreas
Published on: July 25, 2025
Novel blood sampling method of an artificial endocrine pancreas via the cardiopulmonary bypass circuit
Shinji Kawahito1, Seiichi Higuchi, Naoji Mita
1Department of Anesthesiology, Tokushima University Hospital, 3-18-15, Kuramoto, Tokushima, 770-8503, Japan, kawahito@pb4.so-net.ne.jp.
Abstract:
We tried to perform continuous blood glucose monitoring during cardiovascular surgery involving cardiopulmonary bypass using an artificial endocrine pancreas (STG-22 or -55; Nikkiso, Tokyo, Japan); however, we often encountered problems during these procedures because insufficient blood was obtained for monitoring. Thus, we started performing the blood sampling via the venous side of the cardiopulmonary bypass circuit. As a result, continuous blood glucose monitoring using an artificial endocrine pancreas was proven to be stable and reliable during cardiovascular surgery involving cardiopulmonary bypass.
