Related Experiment Video
Updated: May 8, 2026

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
Published on: January 12, 2017
Manual lymphatic drainage in chronic venous disease: a duplex ultrasound study
Rute Sofia Dos Santos Crisóstomo1, Miguel Sandu Candeias2, Ana Margarida Martins Ribeiro3
1Laboratório de Biomecânica e Morfologia Funcional (LBMF), Faculdade de Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1499-002 Lisboa, Portugal Centro Interdisciplinar Para o Estudo da Performance Humana (CIPER), Faculdade de Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1499-002 Lisboa, Portugal Instituto Politécnico de Castelo Branco, Escola Superior de Saúde Dr. Lopes Dias, Castelo Branco, Portugal crisostomo.rute@ipcb.pt/crisostomo.rute@gmail.com.
Insights
Manual lymphatic drainage effectively boosts lower extremity venous blood flow in both healthy individuals and those with chronic venous disease. The specific drainage technique used does not significantly alter this positive hemodynamic effect.
Area of Science:
- Vascular Medicine
- Physiology
- Medical Interventions
Background:
- Chronic venous disease (CVD) affects venous circulation, potentially leading to complications.
- Manual lymphatic drainage (MLD) is a therapeutic technique with potential hemodynamic effects.
- Understanding MLD's impact on venous blood flow is crucial for managing CVD.
Purpose of the Study:
- To compare the effects of two MLD maneuvers (call-up and reabsorption) on venous blood flow.
- To assess these effects in both patients with CVD and healthy controls.
- To investigate the relationship between CVD severity and MLD's hemodynamic impact.
Main Methods:
- Duplex ultrasound was used to measure blood flow parameters in the femoral and great saphenous veins.
- Forty-one participants (23 with CVD, 18 healthy) were included.
- Call-up and reabsorption MLD maneuvers were applied to the thigh, with measurements taken at baseline and during application.
Main Results:
- Both MLD maneuvers significantly increased venous flow volume in the femoral and great saphenous veins in all participants (P < 0.05).
- The hemodynamic effects were similar between the call-up and reabsorption maneuvers.
- Increased CVD severity correlated with reduced flow augmentation from the call-up maneuver (r = -0.64, P = 0.03).
Conclusions:
- MLD enhances lower extremity venous blood flow irrespective of the specific maneuver used.
- The presence or severity of chronic venous disease does not diminish MLD's positive impact on venous flow.
- MLD presents a potential therapeutic strategy for preventing venous stasis complications in CVD.
Objectives:
To compare the effect of call-up and reabsorption maneuvers of manual lymphatic drainage on blood flow in femoral vein and great saphenous vein in patients with chronic venous disease and healthy controls.
Methods:
Forty-one subjects participated in this study (mean age: 42.68(15.23)), 23 with chronic venous disease (chronic venous disease group) with clinical classification C1-5 of clinical-etiological-anatomical-pathological (CEAP) and 18 healthy subjects (control group). Call-up and reabsorption maneuvers were randomly applied in the medial aspect of the thigh. The cross-sectional areas, as well as the peak and the mean blood flow velocity at femoral vein and great saphenous vein, were assessed by Duplex ultrasound at the baseline and during maneuvers. The venous flow volume changes were calculated.
Results:
The venous flow volume in femoral vein and great saphenous vein increased during both manual lymphatic drainage maneuvers and in both groups (P < 0.05). The two maneuvers had a similar effect on femoral vein and great saphenous vein hemodynamics, and in both the chronic venous disease and control groups. As a result of the call-up maneuver, the flow volume augmentations, as a result of call-up maneuver, decreased with the severity of chronic venous disease in those patients measured by the clinical classification of CEAP (r = -0.64; P = 0.03).
Conclusions:
Manual lymphatic drainage increases the venous blood flow in the lower extremity with a magnitude that is independent from the specific maneuver employed or the presence of chronic venous disease. Therefore, manual lymphatic drainage may be an alternative strategy for the treatment and prevention of venous stasis complications in chronic venous disease.
Related Concept Videos
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis IV: Nursing Management
Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

