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Updated: Aug 3, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
Published on: January 31, 2012
[Changes in the synovial medium in deforming gonarthrosis]
Abstract:
The authors have determined the changes in the synovial medium of the joint characteristic of various stages of severity of the disease in 248 patients with deforming gonarthrosis on the basis of arthroscopic and thermographic studies and investigation of the permeability of the synovial membrane in the complex with clinical and roentgenologic examinations. At the initial stages the signs of local reactive inflammation of the synovial membrane near the foci of degeneration of the articular cartilage prevail. For the late stages a trend to spreading of the reactive inflammation of the synovial membrane with the development of sclerotic changes in the previously affected areas is characteristic. A comparison of the results of arthroscopy, infra-red thermography and the permeability of the synovial membrane point at parallel changes in the synovial medium and in the microcirculatory and regional circulation of the knee joint. These findings may be used for working out the rational tactics of treatment of the patients with deforming gonarthrosis.
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