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Updated: May 8, 2026

Mouse Pneumonectomy Model of Compensatory Lung Growth
09:22

Mouse Pneumonectomy Model of Compensatory Lung Growth

Published on: December 17, 2014

Mapping cyclic stretch in the postpneumonectomy murine lung.

Nenad Filipovic1, Barry C Gibney, Milos Kojic

  • 1Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia;

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 31, 2013
PubMed
Summary
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Parenchymal deformation, specifically increased stretch and shear strain in the remaining lung after pneumonectomy (PNX), may trigger compensatory lung growth. These mechanical signals in specific regions are key to understanding lung regeneration.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Pulmonary Physiology

Background:

  • Pneumonectomy (PNX) in mammals stimulates compensatory growth of the remaining lung.
  • The precise mechanisms triggering this lung regeneration remain incompletely understood.

Purpose of the Study:

  • To investigate the hypothesis that parenchymal deformation acts as a mechanical signal initiating lung regeneration post-PNX.
  • To quantify changes in lung tissue mechanics following pneumonectomy.

Main Methods:

  • Respiratory-gated micro-computed tomography (micro-CT) scanning was used to capture lung geometry.
  • Three-dimensional finite-element models of the murine cardiac lobe were created pre-PNX and 24 hours post-PNX.
  • Computational analysis quantified parenchymal stretch ratio and shear strain during cyclic breathing.
Keywords:
finite elementimage registrationlungpneumonectomyregeneration

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Main Results:

  • Post-PNX, lung tissue exhibited heterogeneous mechanical stress, with increased stretch ratios (2-4 fold) and shear strain (up to 3 fold) in specific regions.
  • Subpleural, juxta-diaphragmatic, and cephalad regions showed the most significant mechanical alterations.
  • Some areas experienced parenchymal compression during peak inspiration post-PNX.

Conclusions:

  • Heterogeneous parenchymal deformation, characterized by enhanced stretch and shear strain, provides a plausible mechanical trigger for compensatory lung growth.
  • These findings support the role of cyclic parenchymal stretch as a key signal in initiating lung regeneration after pneumonectomy.