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Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Mismatch Repair01:36

Mismatch Repair

Overview
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Assessment of the Gastrointestinal System II: Health Perception Pattern01:29

Assessment of the Gastrointestinal System II: Health Perception Pattern

Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:

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Related Experiment Videos

Illness perceptions, risk perception and worry in SDH mutation carriers.

L T van Hulsteijn1, A A Kaptein, A Louisse

  • 1Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands, L.T.van_Hulsteijn@lumc.nl.

Familial Cancer
|August 31, 2013
PubMed
Summary

Individuals with succinate dehydrogenase (SDH) mutations perceive less control over their health and experience significant worry. Understanding these perceptions is key for better genetic counseling and support for mutation carriers.

Related Experiment Videos

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Succinate dehydrogenase (SDH) mutations predispose individuals to paragangliomas.
  • Understanding patient perceptions is crucial for managing hereditary tumor syndromes.

Purpose of the Study:

  • To explore illness perceptions, risk perception, and disease-related worry in SDH mutation carriers.
  • To investigate associations between illness perceptions, risk perception, and worry.

Main Methods:

  • Cross-sectional study of SDHB and SDHD mutation carriers at a tertiary referral center.
  • Validated Illness Perception Questionnaire-Revised used for perception assessment.
  • Risk perception and worry measured using specific items; associations explored.

Main Results:

  • SDH mutation carriers perceived less controllability of their condition compared to reference groups.
  • SDHB carriers perceived their condition as less chronic and had greater personal/treatment control than SDHD carriers.
  • Manifest disease carriers reported more negative perceptions and higher tumor risk perception than asymptomatic carriers.

Conclusions:

  • Illness perceptions, risk perception, and worry are strongly correlated in SDH mutation carriers.
  • Interventions targeting illness perceptions could enhance genetic counseling and patient support.
  • Assessing risk perception and worry may be facilitated by understanding illness perceptions.