[The blood flow and catecholamine content in different layers of the myocardium in acute left-ventricular failure]

Four series of acute experiments were conducted on 28 male and female mongrel dogs under general anesthesia and artificial lung ventilation. Each dog weighed 12.5 kg. The catecholamine (CA) concentration and regional blood flow in myocardial layers (RBFML) of the left ventricle of the heart (LV) and in the transmural layer of the right ventricular anterior wall, the values of central hemodynamics, and the general coronary blood flow were determined. During a volume load the RBFML increased by more than twice, the CA content also grew, and there was mainly an increase in the concentration and seizure of adrenaline (A) in the intramyocardial and subendocardial layers of the LV anterior and posterior walls. The noradrenaline (NA) concentration reduced 3 times as compared to the control values. In acute left-ventricular insufficiency (ALI) the RBFML increased significantly in the left-ventricular subepi- and subendocardial layers. The NA and CA concentration reduced significantly in the LV anterior wall and increased significantly in the posterior wall as compared to the control values. The A concentration practically did not change in the LV anterior wall but increased significantly in the posterior wall as compared to the control values. Dosed volume load in ALI led to significant increase of the RBFML in the LV anterior and posterior walls as compared to the values during ALI in the controls. The CA concentration was increased significantly in the myocardial layers of the LV anterior and posterior walls, but it was much higher in the myocardium of the posterior wall than in the myocardium of the anterior wall.(ABSTRACT TRUNCATED AT 250 WORDS)