Related Experiment Video
Updated: May 8, 2026
07:14
Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
Relationship between periodontitis and pre-eclampsia: a meta-analysis.
Fabrizio Sgolastra1, Ambra Petrucci, Marco Severino
1Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Plos One
|August 31, 2013
Summary
Periodontal disease (PD) may increase the risk of pre-eclampsia (PE), according to this meta-analysis. Further research is needed to confirm the association due to study limitations.
Area of Science:
- Obstetrics and Gynecology
- Periodontology
- Public Health
Background:
- Conflicting evidence exists regarding the link between pre-eclampsia (PE) and periodontal disease (PD).
- No previous meta-analysis has synthesized the available research on this association.
Purpose of the Study:
- To conduct a meta-analysis to clarify the potential association between periodontal disease and pre-eclampsia.
Main Methods:
- A comprehensive literature search was performed across electronic databases and journals.
- Meta-analysis followed Cochrane Collaboration and PRISMA guidelines, calculating odds ratios (ORs) and 95% confidence intervals (CIs).
- Heterogeneity was assessed using Cochran Q test and I(2) statistic.
Main Results:
- Fifteen studies (3 cohort, 12 case-control) were included in the analysis.
- A significant positive association was found between PD and PE (OR 2.17, 95% CI 1.38-3.41, P=0.0008).
- High heterogeneity was observed (I(2)=75%), limiting the power of subgroup analyses.
Conclusions:
- Periodontal disease is suggested as a potential risk factor for pre-eclampsia.
- Limitations include variations in PD and PE definitions, diagnostic criteria, and methodological quality across studies.
- High-quality future trials are necessary to validate these findings.
Related Concept Videos
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...