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Localized scleroderma: a clinical study at a single center in Korea
Jung Won Noh1, Jinseok Kim, Jae-Wang Kim
1Depatment of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
International Journal of Rheumatic Diseases
|September 3, 2013
Summary
Localized scleroderma, a rare autoimmune skin disease, primarily affects young females. Treatment outcomes show moderate effectiveness, with 62.8% of patients experiencing improvement.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Rheumatology
Background:
- Localized scleroderma (morphea) is a rare autoimmune skin condition.
- It involves fibrosing and vasculopathy, potentially causing functional disability.
- Limited clinical data exists for Korean patients.
Purpose of the Study:
- To investigate the clinical presentation of localized scleroderma.
- To analyze serological data in patients with localized scleroderma.
- To determine clinical outcomes of localized scleroderma in Korea.
Main Methods:
- Retrospective survey of 43 patients.
- Data collected from 2004-2010 at a single medical center.
- Review of available medical records.
Main Results:
- Predominantly affected females (2.6:1 ratio), with a mean age of 26.2 years.
- Plaque (51.2%) and linear (37.2%) morphea were most common.
- Fluorescent antinuclear antibody positive in 23.3%; 62.8% showed clinical improvement with treatment.
Conclusions:
- Localized scleroderma is a chronic, skin-confined inflammatory disease.
- Diagnosis requires thorough clinical evaluation, including serologic and histopathologic studies.
- Further research is needed to understand treatment efficacy.
