Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Histopathological and Clinicopathological Correlation of Endoscopic Biopsies of Upper Gastrointestinal Tract Lesions.

Cureus·2026

Same author

Lumbar Spine Mucormycosis Mimicking Pott's Spine: A Case Report.

Case reports in infectious diseases·2026

Same author

Clinical, Quality, and Cost Outcomes of Patients With Early-Stage Non-Small Cell Lung Cancer Undergoing Surgery or Stereotactic Body Radiation Therapy.

Annals of thoracic surgery short reports·2026

Same author

Correction: A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy.

Oncotarget·2026

Same author

Influence of Peptide-Based Chelator Sequences on HER2-Targeting Radiopeptide.

Journal of peptide science : an official publication of the European Peptide Society·2026

Same author

Comparative Evaluation of Efficacy of Buccal Infiltration and Intraligamentary Injection with 4% Articaine in Primary Molars: <i>In Vivo</i> Study.

International journal of clinical pediatric dentistry·2026

Search research articles

Related Experiment Video

Updated: May 8, 2026

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

Oncometabolomics in cancer research.

Sonal Gupta¹, Kanika Chawla

¹Department of Pathology, Johns Hopkins University School of Medicine1550 Orleans street, CRB-2, Rm 3M42, Baltimore, MD 21231, USA. sgupta28@jhmi.edu

Expert Review of Proteomics

|September 3, 2013

Summary

Cancer involves complex genetics and altered metabolism. Metabolomics offers a global network view for identifying cancer biomarkers and improving diagnostics, prognostics, and therapeutics.

Area of Science:

Oncology
Metabolomics
Biochemistry

Background:

Cancer is a complex genetic disease characterized by dysregulated bioenergetic metabolism.
Technological advancements enable a shift from studying individual pathways to analyzing global metabolic networks in cancer.

Purpose of the Study:

To review metabolomics techniques and data analysis for cancer research.
To highlight the application of metabolomics in identifying novel cancer biomarkers and therapeutic targets.

Main Methods:

Review of various metabolomics techniques.
Analysis of data generated from metabolomics studies.
Application of metabolomics in cancer research.

Main Results:

More Related Videos

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Related Experiment Videos

Last Updated: May 8, 2026

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Metabolomics provides a global network perspective of metabolic changes in cancer.

Identifies patterns of metabolite expression beyond individual metabolites or pathways.

Enables the discovery of potential diagnostic, prognostic, and therapeutic biomarkers.

Conclusions:

Metabolomics enhances understanding of tumor biology.
Facilitates development of sensitive and specific diagnostic methods.
Supports monitoring of therapeutic efficacy and evaluation of novel treatment strategies.