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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

Emerging technologies for metabolite generation and structural diversification.

Kevin P Cusack¹, Hannes F Koolman, Udo E W Lange

¹AbbVie Bioresearch Center, 381 Plantation Street, Worcester, MA 01605, USA.

Bioorganic & Medicinal Chemistry Letters

|September 3, 2013

Summary

New catalytic methods enable efficient structural diversification of drug molecules. These advanced techniques, including biomimetic catalysis, streamline metabolite production without protecting groups.

Keywords:

Biomimetic oxidation Catalytic transformation Cytochrome P450 Electrochemistry Enzymatic transformation FXTIYMYTRIFRKL-RFGMYIJVSA-K Fluorination LPGJQKSJOQRXJT-YOAFYNBBSA-N Metabolism Metalloporphyrin Microbial metabolism OETMRHBYSHRNMU-UHFFFAOYSA-N QAGYKUNXZHXKMR-HKWSIXNMSA-N SAMJTHBMAUMJNB-UHFFFAOYSA-N SINGGCIFJHSECQ-PFVZUNBHSA-N VDBQDONUIAOUOC-SKXVCGILSA-N WPRSCLYSKGPDBZ-UHFFFAOYSA-N

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Published on: September 23, 2021

Area of Science:

Chemical synthesis
Drug discovery
Catalysis

Background:

Emerging technologies facilitate structural diversification and metabolite production in drug molecules.
Enzymatic, bioorganic, biomimetic catalysis, and electrochemical methods mimic biological systems.
Advancements are expanding transformations beyond oxidation for functionalizing unactivated scaffolds.

Purpose of the Study:

To highlight recent technological advancements in drug molecule synthesis.
To showcase methods for efficient structural diversification of aromatic and aliphatic substrates.
To emphasize single-step reactions that eliminate the need for protecting groups.

Main Methods:

Utilizing enzymatic and bioorganic transformations.
Employing biomimetic catalysis and electrochemical techniques.
Developing efficient catalytic methods for functionalization.

Main Results:

Expanded range of chemical transformations beyond simple oxidation.
Efficient functionalization of unactivated aromatic and aliphatic scaffolds.
Single-step reactions enabling structural diversification without protecting groups.

Conclusions:

Modern catalytic technologies offer powerful tools for drug molecule synthesis.
These methods provide efficient routes to diverse metabolite structures.
The field continues to evolve, enabling more complex and streamlined synthetic processes.