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Related Experiment Video

Updated: May 8, 2026

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Published on: March 22, 2017

Cardiac reprogramming: from mouse toward man.

Deepak Srivastava¹, Emily C Berry

¹Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Roddenberry Center for Stem Cell Biology and Medicine, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

Current Opinion in Genetics & Development

|September 3, 2013

Summary

This summary is machine-generated.

Cardiovascular disease causes irreversible heart cell loss. Direct cardiac reprogramming of fibroblasts into cardiomyocyte-like cells offers a promising new therapy to restore heart function after injury.

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Published on: February 22, 2022

Area of Science:

Regenerative Medicine
Cardiovascular Biology
Cellular Reprogramming

Background:

Cardiovascular diseases lead to irreversible loss of cardiomyocytes, with current treatments unable to restore cardiac tissue after injury.
The limited regenerative capacity of the adult mammalian heart necessitates novel therapeutic strategies.

Purpose of the Study:

To review advances in direct cardiac reprogramming for potential clinical application.
To highlight the potential of reprogramming endogenous cardiac fibroblasts into cardiomyocyte-like cells.

Main Methods:

Discussion of direct cardiac reprogramming techniques.
Review of studies demonstrating fibroblast-to-cardiomyocyte conversion in vivo and in vitro.

Main Results:

Endogenous cardiac fibroblasts can be reprogrammed into cardiomyocyte-like cells.
This reprogramming improves cardiac function following myocardial infarction.

Conclusions:

Direct cardiac reprogramming presents a viable strategy for cardiac repair.
Further research in this field could lead to effective treatments for heart damage.