Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heritability01:06

Heritability

Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic" a trait is,...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European Society for Vascular Surgery (ESVS) 2026 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026
Same author

Two decades of abdominal aortic aneurysm repair in the Nordic countries from 1998 to 2017: A population-based registry analysis.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2026
Same author

Endovascular repair of diseases originating in the ascending thoracic aorta: A systematic review and meta-analysis.

JTCVS structural and endovascular·2026
Same author

Is 5.5 cm Still the Optimal Size Threshold to Treat AAA in Men? A Contemporary Cost-Utility Analysis.

Annals of surgery·2026
Same author

No increased risk of cancer death after endovascular aortic repair in a nationwide population-based cohort study.

The British journal of surgery·2026
Same author

Women with Abdominal Aortic Aneurysms Have a Different Pattern of Genetic Variability, Compared to Men.

Biomedicines·2026

Related Experiment Video

Updated: May 8, 2026

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile
07:42

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile

Published on: July 26, 2024

Pathophysiology of AAA: heredity vs environment.

Martin Björck1, Anders Wanhainen

  • 1Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden. martin@bjorck.pp.se

Progress in Cardiovascular Diseases
|September 3, 2013
PubMed
Summary

Smoking is a key factor in abdominal aortic aneurysm (AAA) development, with genetics also playing a role. Healthier smoking habits are linked to falling AAA rates, highlighting the interplay of lifestyle and inherited predispositions.

Keywords:
AAAAbdominal aortic aneurysmCICholesterolEnvironmentHDLHeredityLDLLRP1ORRTLSNPSmokingTARTelomereabdominal aortic aneurysmconfidence intervalhigh-density lipoproteinlow-density lipoproteinlow-density lipoprotein receptor-related protein 1odds ratiorelative telomere lengthsingle nucleotide polymorphismtelomere attrition rate

More Related Videos

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
11:13

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Related Experiment Videos

Last Updated: May 8, 2026

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile
07:42

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile

Published on: July 26, 2024

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
11:13

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Area of Science:

  • Vascular Biology and Genetics
  • Epidemiology of Cardiovascular Diseases

Background:

  • Abdominal aortic aneurysm (AAA) pathogenesis involves complex interactions between environmental and genetic factors.
  • Smoking is identified as the most significant environmental risk factor for AAA.
  • Declining AAA prevalence in some regions correlates with improved smoking habits.

Purpose of the Study:

  • To review the multifactorial etiology of abdominal aortic aneurysm.
  • To explore the contributions of genetic and environmental influences on AAA development.
  • To discuss the implications of recent genetic and epidemiological findings for AAA research.

Main Methods:

  • Literature review of epidemiological studies on AAA prevalence and risk factors.
  • Analysis of genetic association studies, including genome-wide association studies (GWAS).
  • Examination of twin studies to estimate heritability and genetic contributions to AAA.

Main Results:

  • Smoking cessation and healthier habits are associated with reduced AAA incidence.
  • Family history and twin studies indicate a substantial genetic component in AAA susceptibility.
  • GWAS have identified numerous weak genetic associations, suggesting complex polygenic inheritance.
  • Interactions between genetic and dietary factors, such as those influencing cholesterol levels (HDL, LDL), are implicated.

Conclusions:

  • AAA is a complex disease influenced by both lifestyle and genetic predisposition.
  • Understanding the interplay between genetic susceptibility and environmental factors like smoking and diet is crucial for AAA prevention and management.
  • Further research, including epigenetic studies, is needed to fully elucidate AAA pathophysiology.