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Related Experiment Videos

Pituitary microadenomas: a PET study.

B De Souza1, A Brunetti, M J Fulham

  • 1Neuroimaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Radiology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Positron emission tomography (PET) using fluorine-18-2-fluorodeoxyglucose (FDG) shows promise in diagnosing pituitary microadenomas. PET imaging offers complementary diagnostic value, especially when magnetic resonance imaging (MR) is inconclusive.

Area of Science:

  • Endocrinology
  • Nuclear Medicine
  • Radiology

Background:

  • Pituitary microadenomas require accurate diagnostic imaging.
  • Existing modalities like CT and MR imaging have limitations in detecting small adenomas.
  • Cushing disease and acromegaly are common conditions associated with pituitary microadenomas.

Purpose of the Study:

  • To evaluate the diagnostic performance of fluorine-18-2-fluorodeoxyglucose (FDG) positron emission tomography (PET) for pituitary microadenomas.
  • To compare FDG-PET with computed tomography (CT), magnetic resonance (MR) imaging, and simultaneous bilateral inferior petrosal sinus sampling (SIPS).

Main Methods:

  • Twenty surgically verified pituitary microadenoma cases (17 Cushing disease, 3 acromegaly) underwent FDG-PET.
  • Results were compared with CT, MR imaging, and SIPS (for Cushing disease).

Related Experiment Videos

  • FDG-PET was also performed on 20 healthy controls.

    • Main Results:

    • FDG-PET yielded 12 positive and 1 questionable reading.
    • CT showed 7 positive and 1 questionable reading (18 cases).
    • MR imaging showed 13 positive and 2 questionable readings.
    • FDG-PET identified 5 cases missed or deemed questionable by MR imaging.
    • No false-positive cases were observed in healthy controls with FDG-PET, unlike contrast-enhanced CT (20%) and MR imaging (15%).

    Conclusions:

    • FDG-PET is a valuable tool for diagnosing pituitary microadenomas.
    • FDG-PET complements MR imaging, improving detection rates.
    • FDG-PET demonstrates high specificity, avoiding false positives seen with other modalities in healthy subjects.