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Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position

Kenji Suzuki1, Yoshio Hamada, Jeffrey-Tri Nguyen

  • 1Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

Bioorganic & Medicinal Chemistry
|September 3, 2013
PubMed

Keywords:
Alzheimer’s diseaseHydroxymethylcarbonyl isostereNon-acidic inhibitorQuantitative structure–activity relationshipβ-Secretase

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