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Related Experiment Video

Updated: May 8, 2026

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

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Published on: August 24, 2017

Online tool for calculating null points in various inversion recovery sequences.

Miho Kita¹, Morio Sato, Kazuhiro Kawano

¹Department of Radiology, Seichokai Fuchu Hospital, Izumi, Osaka 594-0076, Japan.

Magnetic Resonance Imaging

|September 3, 2013

Summary

Accurate inversion time null point (TInull) equations are crucial for effective fat and cerebrospinal fluid (CSF) suppression in MRI. This study derived new TInull equations and developed an online tool for precise calculation, improving image quality.

Keywords:

Diffusion-weighted imaging (DWI)Equation Inversion recovery (IR)Magnetic resonance (MR)Null point Spectral attenuated inversion recovery (SPAIR)

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Area of Science:

Medical Imaging
Magnetic Resonance Imaging (MRI)

Background:

Accurate calculation of the inversion time of the null point (TInull) is essential for optimal fat and cerebrospinal fluid (CSF) suppression in inversion recovery (IR) sequences.
Existing methods for TInull calculation are not widely known or easily accessible.

Purpose of the Study:

To elucidate the derivation of accurate TInull equations using clear schematic diagrams.
To develop a convenient online tool for instant TInull calculation.

Main Methods:

Investigated various IR sequences (FLAIR, STIR, SPAIR) classified by longitudinal magnetization behavior.
Derived three accurate TInull equations based on sequence types and magnetization dynamics.
Developed and validated an online TInull calculation tool using pelvic SPAIR diffusion-weighted images in volunteers.

Main Results:

Three accurate TInull equations were successfully derived.
The online tool provides instant TInull calculation based on imaging parameters and tissue T1 values.
Calculated TInull values achieved sufficient fat/CSF suppression, with significant degradation if actual inversion time deviated by >5%.

Conclusions:

The developed online tool offers an easily accessible method for calculating TInull.
This tool enables adequate suppression of fat or CSF, enhancing MRI image quality.
Precise TInull calculation is critical for effective artifact reduction in specific MRI sequences.