Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DSHARP: Deep Incompressible Motion Estimation With Sinusoidal-Transformed Harmonic Phase for Tagged MRI.

IEEE transactions on medical imaging·2026
Same author

Characterization of Inferior Rectus Muscle Action in Normal Subjects Using Real-Time Magnetic Resonance Imaging of the Orbit.

Craniomaxillofacial trauma & reconstruction·2026
Same author

A speech-to-video synthesis approach using spatio-temporal diffusion for vocal tract MRI.

Medical image analysis·2026
Same author

Brain Trauma Foundation Guidelines for the Management of Penetrating Traumatic Brain Injury, Second Edition.

Neurosurgery·2026
Same author

Treatment Algorithms From the Brain Trauma Foundation Guidelines for the Management of Penetrating Traumatic Brain Injury, Second Edition.

Neurosurgery·2026
Same author

Surface tracking-assisted multi-cycle 4D MRI motion modeling for lung radiotherapy: a preliminary validation study.

Biomedical physics & engineering express·2026

Related Experiment Video

Updated: May 8, 2026

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

Default mode network interference in mild traumatic brain injury - a pilot resting state study.

Chandler Sours1, Jiachen Zhuo, Jacqueline Janowich

  • 1Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Brain Research
|September 3, 2013
PubMed
Summary

Mild traumatic brain injury (mTBI) disrupts brain network connectivity, impacting memory. This study reveals altered functional connectivity in mTBI patients, particularly those with memory complaints, affecting key brain networks.

Keywords:
Default mode networkMild traumatic brain injuryResting state fMRIWorking memory

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Related Experiment Videos

Last Updated: May 8, 2026

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Medical Imaging

Background:

  • Mild traumatic brain injury (mTBI) can lead to persistent cognitive deficits, including memory impairments.
  • Understanding the neural underpinnings of these deficits is crucial for developing targeted interventions.
  • Resting-state functional connectivity (rs-fC) analysis offers insights into brain network alterations post-injury.

Purpose of the Study:

  • To investigate functional connectivity differences in mild TBI patients with and without memory complaints.
  • To explore the relationship between altered brain network interactions and memory performance after mTBI.
  • To examine the role of the Default Mode Network (DMN), Task Positive Network (TPN), and Salience Network (SN) in mTBI-related memory deficits.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) was employed in 23 mTBI patients and control participants.
  • Participants were categorized into mTBI with memory complaints and mTBI without memory complaints groups.
  • Neuropsychological assessments, including the Automated Neuropsychological Assessment Metrics (ANAM), were administered.

Main Results:

  • mTBI patients with memory complaints showed significantly poorer memory performance compared to those without.
  • Altered functional connectivity was observed between the DMN, TPN, and SN across the groups.
  • Reduced anti-correlation between DMN and TPN was noted in mTBI patients, with increased TPN-SN connectivity correlating with memory deficits.

Conclusions:

  • Disrupted segregation between the DMN and TPN, potentially mediated by the SN, underlies memory impairments in mTBI.
  • Findings support the Default Mode Interference Hypothesis in the context of mTBI-related memory dysfunction.
  • Altered functional connectivity patterns provide potential biomarkers for memory deficits following mild TBI.