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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Updated: May 8, 2026

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

Nanotechnology and tumor microcirculation.

Mitsunobu R Kano1

  • 1Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dental, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530 Japan.

Advanced Drug Delivery Reviews
|September 3, 2013
PubMed
Summary

Synthesized nanoparticles offer new insights into tumor microcirculation and drug delivery, addressing chemotherapy resistance. Further development of clinically relevant tumor models is crucial for advancing cancer treatment.

Keywords:
CapillaryLeakinessNanomedicineNanoparticleNanotechnologyPathologyPericytePermeabilityVasculature

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Area of Science:

  • Nanotechnology
  • Oncology
  • Pharmacology

Background:

  • Chemotherapeutic refractoriness remains a significant clinical challenge in cancer treatment.
  • Non-autonomous mechanisms, particularly abnormal tumor capillary structures and impaired microcirculation, contribute to poor drug delivery and intratumor accumulation.
  • A comprehensive understanding of tumor microcirculation's functional consequences is needed.

Purpose of the Study:

  • To review the role of synthesized nanoparticles in understanding tumor capillary structure and its functional and therapeutic implications.
  • To explore the potential of nanotechnology in overcoming chemotherapy resistance.
  • To emphasize the need for clinically relevant in vivo and in vitro tumor models.

Main Methods:

  • Review of current literature on tumor microcirculation, chemotherapy resistance, and nanotechnology applications.
  • Analysis of how synthesized nanoparticles can elucidate the functional consequences of abnormal tumor vasculature.
  • Discussion on the development of novel therapeutic strategies utilizing nanoparticles.

Main Results:

  • Synthesized nanoparticles provide novel perspectives on the relationship between tumor capillary structure and drug delivery efficiency.
  • Nanoparticle-based approaches show promise for enhancing intratumor drug accumulation and overcoming refractoriness.
  • The review highlights the potential of nanotechnology to revolutionize anti-tumor chemotherapeutic strategies.

Conclusions:

  • Nanoparticles are emerging as powerful tools to investigate and potentially overcome challenges posed by tumor microcirculation.
  • Further research into nanoparticle-drug conjugates and delivery systems is warranted for improved cancer therapy.
  • Development of robust, clinically relevant tumor models is essential for translating these findings into effective treatments.