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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Recent progresses in gene delivery-based bone tissue engineering.

Chia-Hsin Lu1, Yu-Han Chang, Shih-Yeh Lin

  • 1Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan.

Biotechnology Advances
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

Gene therapy combined with bone engineering accelerates bone repair using therapeutic genes. This review covers new genes, viral vectors, and delivery methods for enhanced bone regeneration.

Keywords:
AAVASCsAcMNPVAdBMP2Autographa californica multiple nucleopolyhedrovirusBMPBMP-2BMSCsBoneCTCXC chemokine receptor-4CXCR4Cox-2DBMECECMEPCsFGF-2FLPFrtGAMGene delivery approachGene therapyHIF-1αIFN-γIL-6LLP2AMDSCsMSCsNZWNew Zealand WhitePDGFPETRANKLRegenerative medicineSATB2Sca-1Stem cellTGF-βTLR-3TNF-αTRAPTissue engineeringVEGFViral vectorsadeno-associated virusadenovirus expressing BMP-2adipose-derived stem cellsbone marrow-derived mesenchymal stem cellsbone morphogenetic proteinbone morphogenetic protein 2computed tomographycycloxygenase-2demineralized bone matrixendothelial cellsendothelial progenitor cellsextracellular matrixfibroblast growth factor-2flippaseflippase recognition targetgene activated matrixhypoxia-inducible factor 1αi.v.iPSCsinduced pluripotent stem cellsinterferon-γinterleukin 6intravenousmesenchymal stem cellsmiRNAmicroRNAmuscle-derived stem cellspeptidomimetic ligandplatelet-derived growth factorpositron emission tomographyreceptor activator of nuclear factor κB ligandsiRNAsmall interfering RNAspecial AT-rich sequence-binding protein 2stem cell antigen-1tartrate-resistant acid phosphatasetoll-like receptor 3transforming growth factor βtumor necrosis factor-αvascular endothelial growth factor

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Gene therapy and bone engineering have merged, focusing on stimulating bone repair.
  • Therapeutic genes are delivered using in vivo or ex vivo approaches.
  • Viral and nonviral vectors are employed for gene administration.

Purpose of the Study:

  • To review fundamental aspects and recent advancements in gene therapy-based bone engineering.
  • To highlight novel genes, viral vectors, and gene delivery strategies.
  • To provide a comprehensive overview of the field's progress.

Main Methods:

  • Literature review of gene therapy applications in bone engineering.
  • Analysis of various gene delivery systems (viral and nonviral).
  • Discussion of in vivo and ex vivo administration approaches.

Main Results:

  • Identification of key therapeutic genes for bone repair.
  • Evaluation of the efficacy and safety of different viral and nonviral vectors.
  • Assessment of emerging gene delivery techniques.

Conclusions:

  • Gene therapy offers significant potential for enhancing bone repair and regeneration.
  • Advances in gene delivery systems are crucial for successful bone engineering applications.
  • Continued research into novel genes and vectors will drive future progress in the field.