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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

[Cerebral microbleeds in cerebrovascular and neurodegenerative diseases]

A V Arablinskiĭ, T A Makotrova, O S Levin

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |September 3, 2013
    PubMed

    Insights

    Cerebral microbleeds (CMBs) are small brain lesions indicating arterial damage. These findings are linked to various neurological conditions and may predict larger bleeds, influencing treatment strategies.

    Area of Science:

    • Neurology
    • Radiology
    • Vascular Biology

    Context:

    • Cerebral microbleeds (CMBs) are identified as small, hypointense lesions on GRE MRI, signifying hemosiderin deposition due to small cerebral artery damage.
    • CMBs are associated with diverse cerebral microangiopathies, including cerebral amyloid angiopathy, hypertensive arteriopathy, vasculitis, and hereditary angiopathies.
    • These microbleeds can serve as a potential predictor for the occurrence of macrobleeds.

    Purpose:

    • To discuss the clinical significance of cerebral microbleeds (CMBs) in the context of cerebrovascular and neurodegenerative diseases.
    • To explore the role of CMBs in cognitive disorders.
    • To evaluate the potential use of antiplatelet agents and anticoagulants in patients diagnosed with CMBs.

    Summary:

    • Cerebral microbleeds (CMBs) are morphological changes in the brain, visualized as small lesions on MRI, indicative of small vessel disease.
    • Their presence is noted across various microangiopathies and they may portend future macrobleeds.
    • The article reviews the clinical relevance of CMBs in neurological conditions and their implications for anticoagulant and antiplatelet therapy.

    Impact:

    • Understanding CMBs is crucial for diagnosing and managing cerebrovascular and neurodegenerative diseases.
    • Identifying CMBs can refine risk stratification for hemorrhagic events.
    • This review informs clinical decisions regarding antithrombotic therapies in patients with CMBs, balancing bleeding risk and thrombotic risk.

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