Related Experiment Video
Updated: May 8, 2026

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling
Saeko Osawa1, Yoshiya Hosokawa, Tetsuji Soda
1Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|September 3, 2013
Summary
This case report details a patient diagnosed with a juxtaglomerular cell tumor (JCT). Selective renal venous sampling proved crucial for pinpointing the tumor
Area of Science:
- Nephrology
- Endocrinology
- Oncology
Background:
- Juxtaglomerular cell tumors (JCTs) are rare renal neoplasms.
- Diagnosis can be challenging due to small tumor size and nonspecific symptoms.
- JCTs can cause secondary hypertension via excess renin production.
Observation:
- A patient presented with a small right kidney lower pole nodule identified via dynamic enhanced computed tomography.
- Selective renal venous sampling revealed elevated plasma renin activity (PRA) localized to the right lower pole renal vein.
- Surgical resection via right partial nephrectomy confirmed the diagnosis of JCT.
Findings:
- The study successfully diagnosed a juxtaglomerular cell tumor (JCT).
- Elevated plasma renin activity (PRA) was lateralized to the affected kidney.
- Dynamic enhanced computed tomography and selective renal venous sampling were key diagnostic tools.
Implications:
- This case underscores the diagnostic value of selective renal venous sampling for JCT.
- Accurate preoperative localization is essential for successful surgical management.
- Early diagnosis and treatment of JCT can prevent complications of renin-mediated hypertension.
Related Concept Videos
Renal Tubule and Collecting Duct
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Renal Drug Excretion: Tubular Secretion
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
Renal Drug Excretion: Tubular Reabsorption
Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
Blood and Nerve Supply to the Kidney
The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
External Anatomy of the Kidney
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...

