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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Neuropathic pain: treatment guidelines and updates
Robert W Hurley1, Meredith C B Adams, Honorio T Benzon
1aDivision of Pain Medicine, Department of Anesthesiology, Psychiatry, Neurology, Orthopaedics and Rehabilitation, University of Florida, Gainesville, Florida bDepartment of Anesthesiology, North Florida/South Georgia Veterans Administration Hospital, University of Florida, Gainesville, Florida cDepartment of Anesthesiology, Northwestern University, Chicago, Illinois, USA *Robert W. Hurley and Meredith C.B. Adams contributed equally to the writing of this article.
Neuropathic pain is underdiagnosed and undertreated, often lacking evidence-based treatments. This review updates the diagnosis, treatment, and prevention of neuropathic pain for improved patient outcomes.
Area of Science:
- Neurology
- Pain Medicine
- Clinical Research
Background:
- Neuropathic pain significantly impacts quality of life and function.
- It arises from diverse nerve injury mechanisms, including infections and diseases.
- Common conditions like radiculopathy have treatments lacking robust evidence.
Purpose of the Study:
- To provide an updated review on neuropathic pain.
- To cover diagnosis, treatment, and prevention strategies.
- To address the current state of neuropathic pain management.
Main Methods:
- Literature review of neuropathic pain.
- Analysis of diagnostic criteria and therapeutic approaches.
- Examination of prevention strategies for specific conditions.
Main Results:
- Neuropathic pain is frequently underdiagnosed and undertreated.
- Many treatments lack sufficient evidence or are untested.
- Prevention strategies can modify pain in conditions like diabetes and HIV.
Conclusions:
- Current treatment paradigms for neuropathic pain require scrutiny.
- An evolving definition broadens therapeutic options.
- A mechanism-based approach is needed for better treatment responses.
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