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Updated: May 8, 2026
Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
Published on: June 4, 2020
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain
Francesca Viganò1, Wiebke Möbius, Magdalena Götz
11] Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University, Munich, Germany. [2] Institute for Stem Cell Research, HelmholtzZentrum, Neuherberg, Germany. [3] Department of Pharmacological Sciences, University of Milan, Milan, Italy.
Abstract:
To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter-derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter-derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.
