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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Impulsivity in panic disorder: neuropsychological correlates.

Katarzyna Jakuszkowiak-Wojten1, Maria Gałuszko-Węgielnik, Alicja Raczak

  • 1Department of Psychiatry, Medical University of Gdańsk, Dębinki 7 st. build. 25, 80-952 Gdańsk, Poland, k.jakuszkowiak@gumed.edu.pl.

Psychiatria Danubina
|September 3, 2013
PubMed
Summary

Patients with panic disorder exhibit higher impulsivity and cognitive deficits. This study links increased impulsivity to impaired episodic memory in individuals with panic disorder.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Impulsivity is linked to various psychopathological conditions, but its relationship with anxiety disorders, particularly panic disorder, is not well understood.
  • Cognitive functioning in anxiety disorders is less explored compared to other mental health conditions.
  • Existing research on cognitive function and impulsivity in anxiety disorders yields inconsistent findings, likely due to methodological variations.

Purpose of the Study:

  • To investigate impulsivity and cognitive functioning in patients with panic disorder.
  • To explore the relationship between impulsivity and episodic memory in individuals with panic disorder.
  • To compare impulsivity and cognitive performance between patients with panic disorder and healthy controls.

Main Methods:

  • Eleven psychotropic drug-naïve patients diagnosed with panic disorder (PD) and nine healthy volunteers participated.
  • Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11).
  • Cognitive functions, specifically episodic memory, were evaluated using the Cambridge Neuropsychological Test Automated Battery (CANTAB) Paired Associate Learning (PAL) test.

Main Results:

  • Patients with panic disorder showed significantly higher mean BIS-11 scores (71.36) compared to healthy controls (60.77).
  • A significant positive correlation was found between impulsivity and episodic memory deficits (PAL results) in the panic disorder group (r=0.708723, p<0.05).
  • A weaker correlation was observed in the control group (r=0.200839, p<0.05).

Conclusions:

  • Individuals with panic disorder exhibit elevated levels of impulsivity compared to healthy individuals.
  • The findings suggest a link between higher impulsivity and cognitive deficits, specifically in episodic memory, among psychotropic drug-naïve patients with panic disorder.