Related Experiment Video

Updated: May 8, 2026

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

Does cirrhotic cardiomyopathy exist? 50 years of uncertainty

Pierpaolo Pellicori1, Concetta Torromeo, Angela Calicchia

  • 1Department of Academic Cardiology, Hull and East Yorkshire Medical Research and Teaching Centre MRTDS (Daisy) Building, Entrance 2 Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK, p.pel@libero.it.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|September 3, 2013
PubMed

Insights

Diagnosing cirrhotic cardiomyopathy, abnormal heart function in liver cirrhosis patients, is challenging due to a lack of clear definition and confounding factors. Early detection may be possible with new imaging and biomarkers.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Subtle cardiac abnormalities, termed cirrhotic cardiomyopathy, are common in liver cirrhosis patients.
  • Diagnosis is challenging due to the absence of a precise definition and confounding factors.
  • Cardiac dysfunction can be masked by treatments or co-existing conditions like anemia.

Purpose of the Study:

  • To highlight the diagnostic challenges of cirrhotic cardiomyopathy.
  • To emphasize the need for research into the specific causes and significance of liver disease-related cardiac dysfunction.
  • To explore potential early detection methods.

Main Methods:

  • Literature review and synthesis of current understanding regarding cirrhotic cardiomyopathy.
  • Analysis of factors complicating the diagnosis of cardiac dysfunction in cirrhosis.
  • Discussion of emerging diagnostic technologies.

Main Results:

  • Cirrhotic cardiomyopathy lacks a standardized definition, complicating diagnosis.
  • Concomitant diseases (hypertension, ischemic heart disease, alcohol use) and treatments (mineral-corticoid receptor antagonists) can obscure cardiac dysfunction.
  • Anemia can also mask cardiac abnormalities.

Conclusions:

  • Further research is essential to define cirrhotic cardiomyopathy and its origins.
  • New imaging tests and plasma biomarkers show promise for early detection of cardiac dysfunction in liver cirrhosis.
  • Accurate diagnosis is crucial for appropriate patient management.

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...