Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
What is Metabolism?00:52

What is Metabolism?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing the Metabolic Profile of Patients Affected by Acute-Onset Neuropsychiatric Syndrome PANS and Tourette Syndrome: Preliminary Data.

Medical sciences (Basel, Switzerland)·2026
Same author

Metabolomic Signatures and Advanced Echocardiography Highlight Clinical Risk and Early Cardiac Changes in Systemic Lupus Erythematosus: Six-Year Follow-Up.

Metabolites·2026
Same author

Spatial multiomics of the breast tumour microenvironment: State of the field, advancements and clinical implementation promises.

Critical reviews in oncology/hematology·2025
Same author

Metabolomics Signatures of Atherosclerosis in Cardiovascular Disease: A Narrative Systematic Review.

Journal of clinical medicine·2025
Same author

Glutaminase inhibitor CB-839 causes metabolic adjustments in colorectal cancer cells.

Scientific reports·2025
Same author

Identification of peripheral biomarkers through metabolomic analysis in patients with bipolar disorder treated with mood stabilizers: an exploratory study.

The international journal of neuropsychopharmacology·2025

Related Experiment Video

Updated: May 8, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Metabolomics in the developing infant.

Vassilios Fanos1, Roberto Antonucci, Luigi Atzori

  • 1aDepartment of Surgery, Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Cagliari bDivision of Neonatology and Pediatrics, Nostra Signora di Bonaria Hospital, San Gavino Monreale cDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Current Opinion in Pediatrics
|September 3, 2013
PubMed
Summary

Clinical metabolomics research in infants is growing, with recent studies focusing on conditions like prematurity and inborn errors of metabolism. Future tools promise easier clinical application for pediatric metabolomics.

More Related Videos

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
09:28

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

Preparation of Frozen Non-Human Primate Fetal Islets for Combined Single Nuclei RNA-Sequencing and ATAC-Sequencing, and Bulk Metabolomics
03:39

Preparation of Frozen Non-Human Primate Fetal Islets for Combined Single Nuclei RNA-Sequencing and ATAC-Sequencing, and Bulk Metabolomics

Published on: November 8, 2024

Related Experiment Videos

Last Updated: May 8, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
09:28

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

Preparation of Frozen Non-Human Primate Fetal Islets for Combined Single Nuclei RNA-Sequencing and ATAC-Sequencing, and Bulk Metabolomics
03:39

Preparation of Frozen Non-Human Primate Fetal Islets for Combined Single Nuclei RNA-Sequencing and ATAC-Sequencing, and Bulk Metabolomics

Published on: November 8, 2024

Area of Science:

  • Neonatal and pediatric metabolomics research.
  • Emerging applications of metabolomic analysis in infant health.

Background:

  • Limited but increasing number of neonatal and pediatric metabolomic studies compared to adults.
  • Growing interest in metabolomics for understanding infant development and disease.

Purpose of the Study:

  • To provide an update on recent publications in clinical metabolomics for developing infants.
  • To highlight the expanding scope of metabolomic research in pediatrics.

Main Methods:

  • Review of recent publications in neonatal and pediatric metabolomics.
  • Analysis of commonly studied fluids (urine, cord blood plasma, milk, stools).

Main Results:

  • Recent studies cover intrauterine growth restriction, prematurity, hypoxic ischemic encephalopathy, metabolic disorders, and nutritional metabolomics.
  • Each condition exhibits a unique metabolite profile, acting as a biological 'barcode'.
  • Urine, cord blood plasma, milk, and stools are frequently analyzed samples.

Conclusions:

  • Metabolomic analysis tools are improving, with potential for clinical integration.
  • Simplified tools like urine 'dipsticks' and integration with other 'omics' will enhance clinical decision-making.
  • Urinary metabolomics is predicted to become a key tool in pediatrics.