[Biocomposite nanostructured materials for the bone defects filling by osteomyelitis].

Area of Science:

• Biomaterials science
• Orthopedic surgery
• Infectious disease treatment

Context:

• Osteomyelitis is a severe bone infection requiring effective treatment strategies.
• Traditional treatments can have limitations in achieving complete bone regeneration and preventing recurrence.
• The development of advanced biomaterials offers new therapeutic possibilities.

Purpose:

• To evaluate the efficacy of the biocomposite nanostructured material "KollapAn" in the surgical treatment of osteomyelitis.
• To assess early anatomical and functional outcomes, wound healing, and complication rates.
• To determine the long-term effectiveness of KollapAn in preventing osteomyelitis recurrence and promoting bone defect substitution.

Summary:

• A study followed 374 patients undergoing 412 operations for osteomyelitis, utilizing the "KollapAn" biocomposite nanostructured material.
• Operations were primarily performed 5-7 days post-necrosequestrectomy, with good early anatomical results in 86% of patients.
• The treatment demonstrated timely wound healing, good functional results, a 1.2% lethality rate (associated with severe sepsis), and no osteomyelitis recurrence in 1.5-year follow-ups, with complete bone defect substitution by autobone.

Impact:

• "KollapAn" demonstrates significant potential as an effective treatment for osteomyelitis, promoting bone regeneration and preventing recurrence.
• The study highlights the successful application of advanced biomaterials in orthopedic infection management.
• This research contributes to improved patient outcomes and reduced long-term morbidity associated with osteomyelitis.