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Updated: May 8, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Nitrous oxide induced myeloneuropathy: a case report.

Matt Rheinboldt¹, Derrick Harper, David Parrish

¹Department of Emergency Radiology, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI, 48202, USA, mrheinbold@yahoo.com.

Emergency Radiology

|September 3, 2013

Summary

Chronic nitrous oxide abuse can cause severe neurological damage, leading to myeloneuropathy. This case highlights the importance of recognizing this condition and initiating prompt vitamin B12 treatment.

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Area of Science:

Neurology
Toxicology

Background:

Nitrous oxide (N2O) abuse is a growing public health concern.
N2O abuse can lead to subacute combined degeneration of the spinal cord.
Early diagnosis and treatment are crucial for managing N2O-induced myeloneuropathy.

Observation:

A 35-year-old male presented with progressive weakness, altered mental status, and gait imbalance.
Physical examination revealed hyperreflexia, finger contractures, and sensory deficits.
Cervical spine MRI showed characteristic T2 signal changes in the dorsal columns.

Findings:

The patient's symptoms and MRI findings were consistent with nitrous oxide-related myeloneuropathy.
Laboratory tests were unremarkable.
Diagnosis was based on clinical presentation, history of N2O abuse, and imaging.

Implications:

This case underscores the neurotoxic effects of chronic nitrous oxide abuse.
High-dose vitamin B12 supplementation is the recommended treatment.
Neurological recovery may be slow and incomplete.