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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Soluble E-cadherin in systemic lupus erythematosus.
Tao Jin1, Katarina Almehed, Yihong Zhu
1From the Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy; and the Department of Obstetrics and Gynecology, Sahlgrenska Cancer Centre, Institute of Clinical Sciences, University of Gothenburg, Göteborg, Sweden.
The Journal of Rheumatology
|September 3, 2013
Summary
Serum soluble E-cadherin (sE-cadherin) is elevated in women with systemic lupus erythematosus (SLE). Higher sE-cadherin levels correlate with inflammation and organ damage, particularly kidney damage in SLE patients.
Area of Science:
- Immunology
- Biochemistry
- Rheumatology
Background:
- E-cadherin is crucial for tissue integrity and immune responses.
- Soluble E-cadherin (sE-cadherin), a cleavage product, is elevated in various diseases.
- Understanding sE-cadherin in systemic lupus erythematosus (SLE) may reveal disease mechanisms.
Purpose of the Study:
- To quantify serum sE-cadherin levels in female SLE patients.
- To investigate associations between sE-cadherin and SLE disease markers.
- To explore the link between sE-cadherin and organ damage in SLE.
Main Methods:
- Serum sE-cadherin analyzed via ELISA in 150 SLE patients and 31 controls.
- Regression analyses used to correlate sE-cadherin with disease variables.
- Comparison of sE-cadherin levels based on organ damage presence.
Main Results:
- SLE patients exhibited higher serum sE-cadherin than healthy controls.
- sE-cadherin positively correlated with age, disease duration, ESR, s-creatinine, and lipids.
- Elevated sE-cadherin was specifically observed in SLE patients with renal damage.
Conclusions:
- Serum sE-cadherin is significantly elevated in women with SLE.
- sE-cadherin levels are linked to inflammation and metabolic factors in SLE.
- Renal damage is a key factor associated with increased sE-cadherin in SLE.
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