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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Related Experiment Video

Updated: May 8, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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ACR/EULAR-endorsed study to develop Diagnostic and Classification Criteria for Vasculitis (DCVAS).

Anthea Craven1, Joanna Robson2, Cristina Ponte3,4

  • 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK. anthea.craven@ndorms.ox.ac.uk.

Clinical and Experimental Nephrology
|September 3, 2013
PubMed
Summary

Developing new diagnostic and classification criteria for systemic vasculitis is crucial. The Diagnostic and Classification Criteria for Vasculitis (DCVAS) study aims to improve diagnosis and treatment for these rare inflammatory blood vessel diseases.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic vasculitides are rare inflammatory blood vessel diseases.
  • Current diagnostic criteria are lacking, leading to diagnostic delays.
  • Advancements in understanding vasculitis necessitate updated classification criteria.

Purpose of the Study:

  • To develop and validate new diagnostic criteria for primary systemic vasculitis.
  • To improve and validate classification criteria for primary systemic vasculitis.
  • To address limitations in current diagnostic and classification approaches.

Main Methods:

  • Multinational observational study adhering to ACR/EULAR guidelines.
  • Incorporates vessel size, clinical data, ANCA testing, biopsy, and imaging.
  • Utilizes pre-defined cases and data-driven algorithms to mitigate circularity.

Main Results:

  • Recruitment of over 2,000 vasculitis patients and 1,500 mimic cases.
  • Data collection from over 100 centers across 31 countries.
  • Aims to create a generalizable and comprehensive dataset.

Conclusions:

  • The DCVAS study will provide validated criteria for diagnosing and classifying primary systemic vasculitis.
  • Improved criteria are expected to enhance diagnostic accuracy and timely treatment.
  • The study's large, diverse dataset will offer insights into vasculitis presentation and outcomes globally.