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Birth parameters and parental height predict growth outcome in children with chronic kidney disease

Doris Franke1, Hülya Alakan, Leo Pavičić

  • 1Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Pediatric Nephrology (Berlin, Germany)
|September 3, 2013
PubMed

Insights

Birth parameters and parental height significantly impact long-term growth in children with chronic kidney disease (CKD). Poor growth outcomes are linked to lower birth weight, length, and parental height, highlighting key predictive factors.

Area of Science:

  • Pediatric Nephrology
  • Growth and Development
  • Chronic Kidney Disease Research

Background:

  • Investigating factors influencing growth in pediatric chronic kidney disease (CKD) stages 3-5.
  • Understanding the long-term growth trajectory for children with CKD is crucial for management.
  • Assessing the role of early life factors in pediatric CKD outcomes.

Purpose of the Study:

  • To analyze the impact of birth parameters and parental height on long-term growth outcomes in children with CKD stages 3-5.
  • To identify predictors of poor growth in this vulnerable pediatric population.
  • To establish the relationship between prenatal and perinatal factors and subsequent growth in children with CKD.

Main Methods:

  • Prospective linear growth investigation in 509 children with CKD (stage 3-5) over a mean follow-up of 4.1 years.
  • Categorization of growth outcome into poor growth (PG; height SDS < -2.0 and/or GH treatment) and good growth (GG; height SDS ≥ -2.0).
  • Multivariate binary logistic regression analysis to determine predictors of poor growth outcome.

Main Results:

  • 55% of children experienced poor growth (PG).
  • Pre-term birth and being small for gestational age were significantly higher in the PG group (43.2% vs 25.6% and 36.8% vs 18.9%, respectively; p < 0.001).
  • Lower birth length, umbilical cord pH, and parental height were significant independent predictors of poor growth (sensitivity 72.8%, specificity 69.3%).

Conclusions:

  • Birth parameters and parental height are independent predictors of growth outcome in children with CKD.
  • Early life factors, including birth measurements and genetics (parental height), play a critical role in long-term growth.
  • These findings emphasize the importance of considering birth history and parental stature in managing growth in pediatric CKD.
Abstract

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