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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Hepatocellular carcinoma in qatar.
K I Rasul1, S H Al-Azawi, P Chandra
1Kakil Ibrahim Rasul, CABM, FRCP, ESMO certified, Senior Consultant Haem/Oncolgy, Al-Amal Hospital, Hamad Medical Corporation, P.O.Box 3050, Doha, Qatar.
The Gulf Journal of Oncology
|September 3, 2013
Summary
Hepatocellular carcinoma (HCC) is more common in males, with Hepatitis C virus (HCV) as the leading cause. Chemoembolization offered the longest median survival for HCC patients.
Area of Science:
- Hepatology
- Oncology
- Epidemiology
Background:
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Hepatitis C virus (HCV) and Hepatitis B virus (HBV) are major etiological factors.
- Understanding HCC epidemiology and treatment outcomes is crucial for improving patient survival.
Purpose of the Study:
- To analyze epidemiological, etiological, treatment, and survival data for HCC patients.
- To evaluate outcomes associated with different treatment modalities for HCC.
- To identify prognostic factors influencing survival in HCC patients.
Main Methods:
- Retrospective analysis of 150 HCC patient records (March 2004-December 2010).
- Descriptive statistics for patient characteristics and disease status (Child-Pugh criteria).
- Kaplan-Meier survival analysis and Cox regression for prognostic factor assessment.
Main Results:
- HCC predominantly affects males (3:1 ratio) with HCV as the most common etiology (45%).
- Chemoembolization showed the longest median survival (27 months).
- Over half of patients (53%) were diagnosed at advanced stages, receiving palliative treatment.
Conclusions:
- HCC incidence and etiology (male predominance, HCV) align with Western European patterns.
- Chemoembolization demonstrates superior median survival among evaluated treatments.
- Early diagnosis through enhanced screening programs is vital to improve HCC patient outcomes.
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