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Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: May 8, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Severe refractory asthma: an update.

Reinier R L Wener1, Elisabeth H Bel

  • 1Dept of Respiratory Medicine, Academic Medical Centre, Amsterdam, The Netherlands. r.r.wener@amc.uva.nl

European Respiratory Review : an Official Journal of the European Respiratory Society
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

Severe refractory asthma affects many patients inadequately controlled by current treatments. This review details advancements in defining, classifying, and developing targeted therapies for severe asthma, aiming to improve patient outcomes.

Related Experiment Videos

Last Updated: May 8, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Pharmacology

Background:

  • Asthma is a complex respiratory condition with a significant subset of patients experiencing inadequate control despite existing therapies.
  • This subgroup is characterized as severe refractory asthma, necessitating advanced management strategies.

Purpose of the Study:

  • To provide an updated review on the latest advancements in understanding and managing severe refractory asthma.
  • To highlight progress in defining phenotypes and developing targeted therapeutic options.

Main Methods:

  • Systematic review of recent literature on severe refractory asthma.
  • Analysis of evolving diagnostic and classification approaches.
  • Overview of novel therapeutic strategies and drug development.

Main Results:

  • Progress in defining severe refractory asthma and establishing systematic patient evaluation protocols.
  • Ongoing efforts in detailed phenotyping to enable personalized treatment selection.
  • Development of new targeted therapies aimed at improving disease control and quality of life.

Conclusions:

  • Accurate definition and phenotyping are crucial for optimizing treatment in severe refractory asthma.
  • Emerging targeted therapies hold promise for improving outcomes in patients with difficult-to-treat asthma.
  • Continued research is essential to address the unmet needs in severe asthma management.