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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
What is the Endocrine System?00:46

What is the Endocrine System?

The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...

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Related Experiment Video

Updated: May 8, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Interactions between endocrine and circadian systems.

Anthony H Tsang1, Johanna L Barclay, Henrik Oster

  • 1Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany Chronophysiology Group, Medical Department I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany School of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Journal of Molecular Endocrinology
|September 3, 2013
PubMed
Summary

Circadian clocks regulate daily rhythms, and their disruption is linked to health issues. This review explores the complex interplay between these clocks and hormones in mammals, impacting overall health.

Keywords:
adipokinescircadian clockscortisolendocrine rhythmmelatonin

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Area of Science:

  • Endocrinology
  • Chronobiology
  • Physiology

Background:

  • Endogenous circadian clocks govern 24-hour physiological and behavioral rhythms in most species.
  • Disruption of circadian rhythms is associated with cognitive decline and increased risk of obesity, diabetes, and cancer.
  • Hormonal factors exhibit diurnal secretion patterns, mediating circadian clock output to peripheral tissues.

Purpose of the Study:

  • To review the mechanisms of clock-hormone interactions in mammals.
  • To examine the role of tissue-specific oscillators in hormonal regulation.
  • To understand how alterations in circadian timing affect endocrine signaling and downstream physiological processes.

Main Methods:

  • Literature review focusing on mammalian circadian clocks and hormonal regulation.
  • Synthesis of current research on clock-hormone crosstalk.
  • Analysis of feedback mechanisms between hormonal signals and circadian regulation.

Main Results:

  • Detailed description of mammalian clock-hormone interaction mechanisms.
  • Elucidation of contributions from various tissue oscillators to hormonal control.
  • Summary of how circadian timing changes impact endocrine signaling and metabolic homeostasis.

Conclusions:

  • Circadian clocks and hormonal systems are intricately linked, influencing physiological and metabolic health.
  • Disruptions in this crosstalk can lead to homeostatic imbalances.
  • Understanding these interactions is crucial for addressing circadian disruption-related diseases.