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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

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Related Experiment Video

Updated: May 8, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Pediatric thyroid cancers: an Indian perspective.

Devendra A Chaukar1, Abhishek D Vaidya

  • 1Head and Neck Oncosurgery, Tata Memorial Hospital, Parel, Mumbai, India.

Indian Journal of Surgical Oncology
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

Pediatric thyroid cancer, though aggressive and often metastatic, has excellent survival rates. Careful treatment is crucial to minimize long-term complications in children with this rare disease.

Keywords:
Childhood cancersDifferentiated thyroid cancersRadioiodineThyroid cancer

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Last Updated: May 8, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Area of Science:

  • Endocrinology
  • Pediatric Oncology
  • Cancer Research

Background:

  • Pediatric thyroid cancer is rare, comprising <5% of all thyroid cancers.
  • Characterized by advanced presentation with frequent lymph node and pulmonary metastases.
  • Despite aggressive behavior, survival rates are notably high.

Purpose of the Study:

  • To review existing evidence on pediatric thyroid cancer management.
  • To provide an Indian perspective on this rare pediatric malignancy.
  • To discuss controversies and current consensus in treatment strategies.

Main Methods:

  • Review of existing literature on pediatric thyroid cancer.
  • Analysis of large prospective studies guiding current consensus.
  • Examination of Indian-specific data and case studies.

Main Results:

  • Pediatric thyroid cancer presents aggressively but has favorable outcomes.
  • Meticulous treatment is essential to avoid therapy-related morbidity.
  • Limited Level I evidence necessitates reliance on consensus from large studies.

Conclusions:

  • Pediatric thyroid cancer requires careful management due to its unique presentation and biology.
  • Balancing aggressive disease characteristics with excellent survival is key.
  • Further Indian-specific research is needed to refine management strategies.