Recurrence patterns and management options in aggressive fibromatosis
Rajaraman Ramamurthy1, Balasubramanian Arumugam, Balasubramaniam Ramanandham
1Department of Surgical oncology, Govt. Royapettah hospital, Kilpauk medical college, Chennai, Tamil Nadu 600014 India ; "RAMA SWATHI", 11/25, 7th main road, Raja Annamalaipuram, Chennai, 600028 Tamil Nadu India.
Indian Journal of Surgical Oncology
|September 3, 2013
Summary
Aggressive fibromatosis, a rare neoplasm, presents unique recurrence patterns. This study suggests surgery as the primary treatment, with radiation for specific cases, and advocates for further multi-institutional trials.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Aggressive fibromatosis (AF) is a rare neoplasm originating from musculoaponeurotic tissues.
- Characterized by local invasion and a high recurrence rate, AF poses significant management challenges.
Purpose of the Study:
- To report institutional experience with aggressive fibromatosis.
- To analyze recurrence patterns and evaluate management strategies for this rare tumor.
Main Methods:
- Retrospective analysis of 36 patients with aggressive fibromatosis treated over 14 years.
- Evaluation of demographic data, treatment modalities, outcomes, and recurrence patterns.
Main Results:
- Demographic patterns were consistent with global data.
- Distinct recurrence patterns, multicentric presentation, and non-random distribution were observed, differing from previous studies.
- Surgery was the primary treatment modality.
Conclusions:
- Surgery is recommended as the primary treatment for aggressive fibromatosis.
- Radiation therapy is reserved for patients with positive margins, inoperable tumors, or multiple lesions.
- A 'wait and watch' policy for adjuvant radiation is suggested due to the disease's long natural history, with a call for prospective multi-institutional randomized controlled trials.
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