Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Narcolepsy01:07

Narcolepsy

Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibodies against influenza A/H1N1pdm2009 and B/Victoria strains but not A/H3N2 are increased in recent onset type 1 narcolepsy versus matched controls.

medRxiv : the preprint server for health sciences·2026
Same author

Redefining hypersomnia disorders in the context of psychiatry.

L'Encephale·2026
Same author

To diagnose Narcolepsy type 1 after a negative Multiple Sleep Latency Test: the contribution of systematic hypocretin measurement.

Sleep·2026
Same author

A Two-Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort.

Annals of clinical and translational neurology·2026
Same author

The Brain Imaging and Neurophysiology Dataset of large-scale multimodal neural data.

Scientific data·2026
Same author

Ancestry-specific and multi-ancestry genome-wide association studies of restless legs syndrome.

medRxiv : the preprint server for health sciences·2026
Same journal

Correspondence regarding "Obstructive sleep apnea and primary snoring in children are associated with oropharyngeal dysbiosis and a mild compositional imbalance in the gastrointestinal tract".

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same journal

Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same journal

Glucagon-like peptide receptor agonists (GLP-1RAs) as cardiovascular risk modifiers in obstructive sleep apnea and obesity: a real-world study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same journal

Guideline clarification: dropout in FDA-cleared dCBT-I is comparable to pharmacotherapy and therapist-delivered CBT-I.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same journal

Reply to "Validating the psychomotor vigilance task cutoff for residual excessive daytime sleepiness in treated obstructive sleep apnea".

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same journal

Dr. AI says you have sleep apnea: measuring the accuracy of patient-facing AI in sleep medicine.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Disrupted nighttime sleep in narcolepsy.

Thomas Roth1, Yves Dauvilliers, Emmanuel Mignot

  • 1Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA. TRoth1@hfhs.org

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

Disrupted nighttime sleep (DNS) in narcolepsy is characterized by fragmented sleep and frequent awakenings. Experts recommend clinicians consider DNS a treatment target for patients with narcolepsy.

Keywords:
Narcolepsyconsolidated sleepdisrupted nighttime sleepfragmented nighttime sleepsleep fragmentation

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Related Experiment Videos

Last Updated: May 8, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Area of Science:

  • Neurology
  • Sleep Medicine
  • Clinical Research

Background:

  • Narcolepsy is a chronic neurological disorder affecting sleep-wake regulation.
  • Disrupted nighttime sleep (DNS) is a significant and often distressing symptom in narcolepsy patients.

Purpose of the Study:

  • To establish a consensus characterization of disrupted nighttime sleep (DNS) in narcolepsy.
  • To highlight the importance of DNS as a key symptom of narcolepsy.

Main Methods:

  • A panel of international narcolepsy experts convened to define DNS.
  • A comprehensive literature search was conducted across major biomedical databases (Medline, Embase, Biosis).
  • The panel reviewed identified literature to characterize nighttime sleep disturbances in narcolepsy.

Main Results:

  • Nighttime sleep in narcolepsy is consistently characterized as fragmented.
  • Patients report frequent, brief awakenings with difficulty returning to sleep, leading to poor sleep quality.
  • Polysomnography confirms frequent awakenings, increased Stage 1 sleep, and more frequent shifts from deeper sleep stages.

Conclusions:

  • Disrupted nighttime sleep (DNS) is a distressing symptom in narcolepsy.
  • Clinicians should actively inquire about and consider the patient's nighttime sleep experience.
  • DNS should be recognized and treated as a therapeutic target in narcolepsy management.