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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

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Published on: November 10, 2021

Bisphenol a in chronic kidney disease.

Emilio González-Parra¹, Jose Antonio Herrero, Usama Elewa

¹Servicio de Nefrología, IIS-Fundación Jiménez Díaz and IRSIN, Madrid, Spain ; Unidad de Dialisis, Servicio de Nefrología, IIS-Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain ; Universidad Autónoma de Madrid, Spain.

International Journal of Nephrology

|September 3, 2013

Summary

p-cresol and Bisphenol A (BPA) are phenols linked to health issues. While BPA is an environmental toxicant, its specific risks for chronic kidney disease (CKD) patients, especially those on dialysis, require further study.

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Published on: June 2, 2022

Area of Science:

Toxicology
Nephrology

Background:

Phenols, such as p-cresol, are intestinal uremic toxins linked to kidney and vascular damage.
Bisphenol A (BPA), a plastic-derived chemical, shares structural similarities with phenols and is recognized as an environmental toxicant.
BPA use has been restricted in infant products due to health concerns.

Purpose of the Study:

To review the current understanding of Bisphenol A (BPA) exposure in patients with chronic kidney disease (CKD).
To evaluate the potential risks of BPA for end-stage renal disease (ESRD) patients, particularly those undergoing dialysis.

Main Methods:

Literature review of studies on phenols, p-cresol, and Bisphenol A (BPA).
Analysis of BPA excretion, serum levels in uremic patients, and potential exposure routes during dialysis.

Main Results:

Uremic patients exhibit higher serum levels of BPA.
There is currently insufficient evidence to establish BPA cut-off levels or definitively link it to adverse effects in CKD.
BPA is excreted via the kidneys and may be encountered during dialysis.

Conclusions:

The renal elimination and potential dialysis exposure necessitate monitoring of BPA in CKD patients.
Further observational studies are crucial to assess the health risks of BPA in end-stage renal disease (ESRD) patients.