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Updated: May 8, 2026
A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
Published on: October 16, 2015
In vitro biological screening of the stem of Desmodium elegans
Arshad Khan1, Rabia Usman, Abdur Rauf
1School of Chemistry and Chemical Engineering Southeast University Nanjing, 211189 China. arshad_yousafzai45@yahoo.com
Objective:
To explore the medicinal importance of the stem of Desmodium elegans, methanolic extract, and its different solvent fractions were evaluated for brine shrimp lethality, insecticidal and phytotoxicity, antifungal, and antibacterial activities.
Methods:
The methanolic extract and its solvent fractions were tested for cytotoxic, phytotoxic, insecticidal, antifungal, and antibacterial effects using our previous published protocols.
Results:
The methanolic, DCM, ethyl acetate and n-butanol fractions exhibited insecticidal effect against Callosobruchus analis and Rhyzopertha dominic. The methanolic extract, n-hexane, DCM ethyl acetate and n-butanol showed 75, 85, 85, 65 and 5% phytotoxicity at the tested concentration of 500 µg/mL respectively. The solvent fractions (DCM and ethyl acetate) were effective against F. solani (10% and 20% inhibition respectively). All the tested samples were devoid of cytotoxic and antibacterial effects.
Conclusion:
It was concluded that this plant can be practiced for control of weeds and insects.
